Preventing MRSA
The interventions that work are unglamorous and well-studied: clean hands, covered wounds, no shared personal items, and disciplined antibiotic use. The specifics change by setting.
Where do you want to prevent MRSA?
In hospitals and after surgery
The evidence-based bundle: hand hygiene, chlorhexidine bathing, screening, contact precautions and surgical prophylaxis.
Read more →At home and protecting family
Wound care, laundry, cleaning, no shared items, and what to do after known household exposure.
Read more →Sports, gyms and locker rooms
Skin checks, covered wounds, no shared towels or razors, cleaning shared gear, and when to pull an athlete.
Read more →Intimacy and sexual transmission
MRSA isn't a classical STI but spreads through skin-to-skin contact. When to abstain and how to reduce risk.
Read more →Why MRSA keeps coming back
Recurrent MRSA is a colonisation problem. How decolonisation with mupirocin and chlorhexidine works.
Read more →Bactroban (mupirocin)
The topical antibiotic used to clear MRSA from the nose during decolonisation.
Read more →Chlorhexidine
The antiseptic behind daily hospital bathing, pre-surgical showers and home decolonisation.
Read more →Is there an MRSA vaccine?
No vaccine exists yet. Why the trials failed, what is in development, and what protects you meanwhile.
Read more →MRSA Prevention Policies — The Evidence-Based Bundle
Each bold heading below links to a fuller guide to that policy.
- Hand hygiene — Washing or sanitising hands at the right moments removes MRSA before it reaches a wound, a device or another person. No other prevention measure has a bigger effect for less effort.
- Covered wounds — MRSA leaves the body in wound fluid and pus. A clean, dry, intact dressing keeps the organism inside the dressing rather than on hands, clothing, furniture and other people.
- Don't share personal items — MRSA survives on fabric, plastic and metal for days to weeks. Shared towels, razors, bar soap and sports gear move it directly from one person's skin to another's.
- Screening and contact precautions — Finding MRSA carriers on admission and managing them with gowns, gloves and single rooms stops silent carriage becoming ward-wide transmission.
- Disinfection of high-touch surfaces — Bed rails, door handles, taps, phones, keyboards and remote controls are touched dozens of times an hour. Cleaning them on a schedule removes the reservoir hands keep returning to.
- Antimicrobial stewardship — Every unnecessary antibiotic course selects for resistant organisms. Stewardship — right drug, right dose, right duration, or none at all — reduces the pressure that lets MRSA thrive.
These measures work as a bundle rather than in isolation: screening without decolonisation, or contact precautions without reliable hand hygiene, produce far weaker results than the whole set applied together. Limiting unnecessary antibiotic exposure reduces the selective pressure that favours resistant organisms — stewardship programmes have been associated with measurable declines in MRSA bacteraemia in every system that has run them.
Prevention in the news
Latest headlines and research on MRSA prevention.
See allWhy MRSA comes back
Colonisation and decolonisation protocols.
Mupirocin (Bactroban)
How the nasal decolonisation antibiotic works.
Chlorhexidine
The antiseptic used for daily bathing, pre-surgical showers and decolonisation.
Is there an MRSA vaccine?
Why no vaccine exists, the trials that failed and what protects you instead.
Is MRSA contagious?
How MRSA spreads, for how long, and how to stop it in each setting.
- CDC. Methicillin-resistant Staphylococcus aureus (MRSA) — Prevention (2024)
- World Health Organization. Antimicrobial resistance — fact sheet (2023)
- Liu C. et al., IDSA. Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of MRSA Infections (2011)
- Cochrane Database of Systematic Reviews. Antibiotics for preventing meticillin-resistant Staphylococcus aureus (MRSA) infection (2017)
- NICE. Healthcare-associated infections: prevention and control (PH36) (2017)
